Antioxidative kev ua ntawm Ferulic Acid
Lub antioxidant nkaus mechanism ntawmferulic acidyog qhov nyuaj, feem ntau yog los ntawm kev txwv ntawm kev tsim cov hom pa oxygen (ROS) lossis nitrogen, tab sis kuj muaj qhov nruab nrab ("cheb") ntawm cov dawb radicals. Ntxiv rau, cov kua qaub no yog lub luag haujlwm rau chelating tiv thaiv cov hlau ions, xws li Cu (II) lossis Fe (II). Ferulic acid tsis yog tsuas pub dawb radical scavenger, tab sis kuj yog ib qho inhibitor ntawm cov enzymes uas catalyze dawb radical tiam thiab kev txhim kho ntawm scavenger enzyme kev ua si. Nws yog ncaj qha ntsig txog nws cov qauv tshuaj. Nws cov khoom tiv thaiv kev tiv thaiv yog feem ntau cuam tshuam rau kev sib cais ntawm cov dawb radicals, khi kev hloov pauv hlau xws li hlau thiab tooj liab, thiab lipid peroxidation tiv thaiv. Lub tshuab ua haujlwm ntawm cov tshuaj tiv thaiv kev ua haujlwm ntawm ferulic acid yog lub peev xwm los ua kom ruaj khov phenoxyl radicals, los ntawm cov tshuaj tiv thaiv ntawm cov tshuaj tiv thaiv radical nrog cov txheej txheem ntawm cov tshuaj antioxidant. Qhov no ua rau nws nyuaj los pib ua ib cov tshuaj tiv thaiv nyuaj uas ua rau tiam dhau los ntawm cov dawb radicals. Cov kab ke no tseem tuaj yeem ua raws li hydrogen pub dawb, muab cov atoms ncaj qha rau cov radicals. Qhov no yog qhov tshwj xeeb tshaj yog rau kev tiv thaiv cell membrane lipid acids, los ntawm cov txheej txheem ua tsis tau autoxidation. Raws li lub zog ua kom muaj cov tshuaj tua kab mob hauv lub cev, ferulic acids thiab lawv cov sib txuas sib txuas tau tuaj yeem khi cov kev hloov hlau xws li hlau thiab tooj liab. Qhov no tiv thaiv kev tsim cov tshuaj lom neeg hydroxyl radicals, uas ua rau lub cell membrane peroxidation.
Dawb radicals kuj tuaj yeem tsim los ntawm cov txheej txheem tib neeg muaj sia hauv lub cev, xws li cov txheej txheem ua pa ntawm tes. Cov kev cuam tshuam no yog catalyzed los ntawm qee cov enzymes, ntawm lwm tus xanthine oxidase thiab cyclooxygenase-2. Nws tau pom zoo tias qhov inhibition ntawm enzyme no tuaj yeem tiv thaiv kev hloov pauv los ntawm oxidative kev nyuaj siab, suav nrog photophobia. Cov ntaub ntawv cov ntaub ntawv tshaj tawm qhia txog kev ua tau zoo ntawm ferulic acid thiab nws cov txiaj ntsig zoo hauv kev txo xanthine oxidase thiab kev ua haujlwm cyclooxygenase. Nws yog li ntawd ntseeg tau tias ferulic acid txo qhov ntau npaum li cas ntawm ROS tsim los ntawm kev hloov pauv enzyme-catalyzed.
Qhov nruab nrab ferulic acid cov ntsiab lus nyob hauv cov zaub mov xa tawm