Urolithin ib (tom qab no hu ua UA) yog ib qho metabolite ntawm cov kab mob hauv plab hnyuv thiab tsis tuaj yeem raug ntxiv ncaj qha los ntawm kev noj zaub mov. Txawm li cas los xij, nws cov precursor ellagitannin yog nplua nuj nyob rau hauv pomegranate, strawberry thiab lwm yam txiv hmab txiv ntoo.

Thawj qhov kev sib ntsib ntawm tib neeg thiab UA tuaj yeem taug qab rov qab mus rau xyoo 2005. Pab pawg tshawb fawb ntawm tus kws tshawb fawb CERD á thawj zaug pom qhov muaj nyob ntawm urolithin A thiab lees paub tias nws yog kev ua haujlwm ntawm plab microbiota.

Hauv kaum xyoo tom ntej no, tus naj npawb ntawm cov kev tshawb fawb ntawm UA tau tuav txoj kev loj hlob tsis tu ncua, thiab nws cov kev ua haujlwm nplua nuj ntawm kev tiv thaiv oxidation, tiv thaiv qog noj ntshav, tiv thaiv kab mob thiab tiv thaiv kab mob tau pom ib qho tom qab. Cov khoom siv yees siv no tau muab los ntawm cov xwm txheej tau los rau hauv kev pom ntawm ntau thiab ntau tus kws tshawb fawb.

Yog li, dab tsi yog qhov txheej txheem tom qab cov yeeb yuj ua haujlwm ntawm urolithin ib? Nws pab cov kab mob li cas tiv thaiv kev laus thiab ua kom lub neej ntev?

No.1anti aging

Txij li thaum nws tau pom nyob rau hauv 2016 tias nws muaj peev xwm ua tau zoo ncua lub neej ncua sij hawm ntawm Caenorhabditis elegans, lub anti-aging efficiency ntawm urolithin a nyob rau hauv ntau theem (hematopoietic qia hlwb, daim tawv nqaij cov ntaub so ntswg, hlwb (cov kabmob), lub cev tsis muaj zog, ib tug neeg lub neej ncua) thiab hom (Caenorhabditis elegans, Drosophila melanogaster, nas, tib neeg) tau pom zoo.

Cov kws tshawb fawb kuj tau muab cov lus piav qhia tsim nyog rau cov txheej txheem tom qab nws.

Hauv kev sim tsiaj thiab kev sim tshuaj, cov kws tshawb fawb tau pom tias UA tuaj yeem cuam tshuam qhov kev loj hlob ntawm kev laus mitochondrial tsis ua haujlwm thiab ua kom lub neej ntev ntawm mitochondria los ntawm inducing autophagy ntawm dysfunctional mitochondria thiab tswj mitochondrial biosynthesis, thiab tseem tuaj yeem ua rau mitosis ntawm cov hlwb. cov teebmeem ntawm kev laus.

Lus Cim: Raws li ib qho mitotic inducer, urophyllin tuaj yeem kho qhov poob ntawm mitosis los ntawm kev laus.

Tom qab nyeem cov txheej txheem, cia peb saib cov lus nug uas txhawj xeeb tshaj plaws: qhov kev tiv thaiv kev laus ntawm UA ua li cas hauv tib neeg kev sim tshuaj?

Txog tam sim no, kev sim tshuaj tib neeg ntawm kev tiv thaiv kev laus ntawm UA feem ntau tau tsom mus rau kev txhim kho cov teeb meem ntawm cov leeg pob txha muaj hnub nyoog (tej zaum vim tias qhov kev txhim kho zoo dua tuaj yeem tshwm sim thiab yooj yim rau kev soj ntsuam). Ntau qhov kev tshawb fawb tau lees paub qhov kev nyab xeeb zoo thiab bioavailability ntawm UA hauv tib neeg.

Tsis tas li ntawd, nyob rau hauv cov kev tshawb fawb no, cov kws sau ntawv tau hais tias UA ua lub luag haujlwm tiv thaiv kev laus los ntawm kev txhim kho mitosis thiab mitochondrial kev ua haujlwm ntawm cov hlwb sib xws, uas tseem ua raws li cov txheej txheem hais saum toj no.

Lwm qhov nthuav qhia yog tias UA tau txhim kho kev ua siab ntev thiab lub cev muaj zog ntawm cov neeg laus hauv cov kev sim no, tab sis tsis tuaj yeem txhim kho qhov kev ua tau zoo tshaj plaws ntawm kev ua ub no, uas kuj qhia txog tus kheej ntawm UA raws li kev tswj hwm kev ua haujlwm ntau dua li lub suab nrov.

No.2 muaj peb cov teebmeem classic: anti-inflammatory, antioxidant thiab anticancer

Tom qab ua tiav cov anti-aging protagonist, cia peb saib thawj zaug thiab feem ntau tau kawm peb yam tseem ceeb ntawm UA: anti-inflammatory, antioxidant thiab anti-cancer.

Qee cov kws tshawb fawb tau lees paub tias UA tuaj yeem cuam tshuam mitochondria ntsig txog apoptosis txoj hauv kev thiab tswj P-38 MAPK teeb liab txoj hauv kev, yog li inhibiting oxidative stress-induced apoptosis. Piv txwv li, UA tuaj yeem txhim kho qhov ciaj sia taus ntawm cov neurons txhawb nqa los ntawm oxidative kev nyuaj siab thiab muaj txiaj ntsig zoo neuroprotective.

Daim ntawv ceeb toom: UA tej zaum yuav zoo li cov yeeb yaj kiab tshiab ntawm cov txiv hmab txiv ntoo rau lub cev.

Yees duab: https://vinepair.com/articles/what-is-oxidation-in-wine/

Piv nrog rau nws cov antioxidant muaj peev xwm, UA muaj ntau zog los tiv thaiv inflammatory kev ua si thiab muaj peev xwm ho inhibit TNF- Thiab lwm yam inflammatory yam, uas yog vim li cas UA plays lub luag hauj lwm nyob rau hauv ntau yam inflammatory kev kho mob, nrog rau lub paj hlwb, rog, plawv, hnyuv thiab daim siab nqaij, thiab tuaj yeem txo qhov mob ntawm ntau yam ntaub so ntswg.

Hauv cov qauv ntawm tib neeg lub cev, UA tau raug lees paub los ua lub luag haujlwm tiv thaiv kab mob los ntawm kev ua kom apoptosis thiab thaiv lub voj voog ntawm tes, nrog rau mob qog noj ntshav thiab mob qog noj ntshav prostate yog qhov tseem ceeb tshaj plaws.

No.3 tiv thaiv nyhuv: paj hlwb, plab hnyuv thiab plawv

Nyob rau theem system, UA kuj tau ua pov thawj tias muaj kev tiv thaiv zoo heev ntawm lub paj hlwb, kab mob plab thiab kab mob plawv. Nws tuaj yeem hais tias yog peb tus neeg saib xyuas kev noj qab haus huv zoo heev.

Piv txwv li, nyob rau hauv cov kab mob neurodegenerative tshwm sim los ntawm kev laus, kev tshawb fawb tau tshaj tawm tias UA tuaj yeem qhib SIRT1 teeb liab txoj hauv kev, txo qis mTOR teeb liab txoj hauv kev, thiab qhib autophagy los tiv thaiv D-galactose-induced hlwb laus, yog li txhim kho kev txawj ntse hauv cov nas laus.

No.4 txhim kho kev rog thiab tswj cov hnyuv ib puag ncig

Tsis tas li ntawd, cov kev tshawb fawb tau pom tias UA muaj cov txiaj ntsig zoo ntawm kev txhim kho kev rog thiab tswj cov plab hnyuv ib puag ncig. Txawm li cas los xij, vim muaj kev txwv qhov chaw, hnub no, paipai yuav tsis qhia ntau ntxiv ntawm no.

Tau hais ntau dhau lawm, tus phooj ywg yuav tsum tau txhawj xeeb nug, UA muaj txiaj ntsig ntau, thiab nws yog cov khoom lag luam ntshiab uas tau los ntawm cov txiv hmab txiv ntoo thiab zaub, yog li peb tuaj yeem ntxiv UA hauv peb lub neej li cas?

Ntuj zoo dua? Tsis muaj! Kev ua haujlwm yuav zoo dua!

Raws li khoom plig los ntawm xwm, lub precursor ntawm UA,ellagitannin ua, muaj cov ntsiab lus siab hauv ntau hom nroj tsuag thiab txiv hmab txiv ntoo. Pie ncuav qab zib kuj tau txheeb xyuas lub rooj sib tham rau koj siv hauv qab no:

Ellagitannins thiab ellagic acid cov ntsiab lus hauv cov khoom noj

Ntawm qhov tod tes, kev tsim khoom lag luam ntawm UA kuj tuaj yeem ua tiav los ntawm kev siv tshuaj lom neeg, thiab nws txoj kev nyab xeeb tau raug pov thawj los ntawm ntau cov kev tshawb fawb toxicological.

Qhov tseeb, raws li thaum ntxov xyoo 2018, UA tau raug xaiv los ua "pom zoo" cov khoom noj khoom haus los ntawm US Food and drug Administration, uas tuaj yeem muab ntxiv rau cov protein milkshakes, hloov pluas noj, instant oatmeal, noj zaub mov muaj protein ntau thiab mis nyuj haus (nce mus txog 500 mg / share), Greek yogurt, high protein yogurt thiab mis nyuj protein milkshakes (txog 1000 mg / qhia).

Ntxiv mus, cov kev tshawb fawb tseem ceeb kuj tau lees paub tias kev tswj hwm qhov ncauj ncaj qha ntawm UA tuaj yeem txhim kho UA cov ntsiab lus hauv cov ntshav thiab ua tiav cov txiaj ntsig kev noj qab haus huv zoo ib yam li kev noj UA nplua nuj xws li kua txiv pomegranate.

Metabolic synthesis sib txawv ntawm cov neeg, UA: kuv zoo, tej zaum koj yuav tsis txaus siab rau nws

Hais txog UA supplementation, lwm yam xov xwm phem yog hais tias ntxiv cov khoom noj uas nplua nuj nyob rau hauv UA precursors tej zaum yuav tsis zoo rau tag nrho cov tib neeg.

Qhov laj thawj rau qhov tshwm sim tsis ncaj ncees yog vim qhov sib txawv ntawmplab hnyuv microbeshauv tib neeg lub cev.

Duab qhov chaw:https://decodeage.com/blogs/gut-microbiome/11-health-benefits-of-urolithin-a-on-ageing-muscle-endurance-and-gut-health-1

Ib txoj kev tshawb fawb los ntawm Tom á s-barber á n hauv 2014 qhia tias tib neeg tuaj yeem muab faib ua peb phenotypes raws li qhov sib txawv metabolic thiab hluavtaws muaj peev xwm ntawm urolithin, uas yog, "phenotype a", "phenotype B" thiab "phenotype 0". Ntawm lawv, tsuas yog cov neeg uas muaj metabolic phenotype a tuaj yeem ua ke ntau ntawm urolithin ib txwm. ROC í o Garc í a-villalba pom qhov thib plaub phenotype hauv xyoo 2019, "R", thiab cov pejxeem zoo li no kuj tsis tuaj yeem ua ke urolithin a.

Cite:Ellagic Acid Metabolism los ntawm tib neeg lub plab Microbiota: Kev soj ntsuam ib txwm ntawm Peb Urolithin Phenotypes hauv Kev Tshawb Fawb Kev Tshawb Fawb, Kev ywj pheej ntawm cov khoom noj, hnub nyoog, thiab kev noj qab haus huv (https://pubs.acs.org/doi/10.1021/jf5024615)

Interestingly, lwm cov kev tshawb fawb tau pom tias muaj kev sib raug zoo ntawm urolithin metabolic phenotype thiab kev laus. Hauv cov neeg laus noj qab nyob zoo ({{{0}}} xyoo), phenotype A suav txog li 70-80% thiab phenotype B txog li 10-20%. Nrog rau cov hnub nyoog nce (30-90 xyoo), qhov feem pua ​​​​ntawm phenotype poob qis, qhov feem pua ​​​​ntawm phenotype B nce, thiab thaum kawg mus txog 50% thiab 40%, feem, thaum qhov kev faib ua feem ntawm phenotype 0 (10%) tseem nyob. yeej tsis hloov.

Tau kawg, yog tias koj hmoov tsis pom koj tus kheej tsis yog ib tug tswv cuab ntawm "Vajtswv xaiv ib tug", koj tsis tas yuav tu siab heev. Peb tsis tuaj yeem ntxiv UA los ntawm kev noj zaub mov. Raws li tau hais los saum no, qhov ncauj UA kuj muaj txiaj ntsig, lossis zoo dua.

Xi'an Green Spring Technology Co., Ltd. Peb tau koom nrog hauv kev tsim khoom thiab muag khoom ntawm Urolithin Ib Powder rau ntau tshaj 22 xyoo. Peb tsim cov khoom qab zib zoo tshaj plaws, suav nrog stevia extract, erythritol, aloketose, momordica grosvenorii extract, thiab lwm yam. Nyob rau tib lub sijhawm, peb tuaj yeem kho cov khoom qab zib raws li koj xav tau.