Kev siv cov khoom cua txias
NtujCov tshuaj ua kom txiasxws li menthol, menthone, methyl acetate thiab peppermint roj yog siv los tsim kom muaj kev zoo siab ntawm qhov txias thiab freshness thaum muab cov ntxhiab tsw mint. Lawv tau siv dav hauv cov khoom siv niaj hnub xws li da dej gels thiab tshuaj zawv plaub hau. Vim qhov ua rau muaj kev cuam tshuam ntawm cov cua txias ntawm lub qhov muag thiab qhov ntswg thiab qhov yuav tsum tau siv cov koob tshuaj loj dua, lawv cov kev siv hauv cov khoom noj khoom haus yog txwv. Lawv daim ntawv thov hauv cov zaub mov tsuas yog txwv rau zom cov pos hniav thiab mints. Tsuas yog nyob rau hauv cov khoom no yog lawv tsim los ntawm "tsis-txias nyhuv" cuam tshuam nrog cov neeg ua haujlwm txias yog feem ntau txais.
Txhawm rau siv cov khoom ua kom txias rau lwm qhov chaw thiab tsim cov pos hniav thiab lwm yam khoom siv nrog cov khoom qab zib uas tsis yog mint, kev txhim kho cov khoom ua kom txias tshiab yog qhov ceev thiab tau dhau los ua txoj haujlwm nyuaj. Txij li thaum xyoo 1970s, ntau yam khoom siv hluavtaws nrog lub siab txias tau tsim thiab siv dav hauv kev lag luam edible tsw. Ua raws li kev ua haujlwm ntawm Watson thiab cov npoj yaig ntawm Wilkinson ntaj hauv thaj chaw ntawm cov khoom cua txias, kev tshawb fawb hauv cheeb tsam no tau nyiam ntau ntxiv. Piv nrog rau menthol, cov khoom ua kom txias no muab qhov ua kom txias txias tsis muaj qhov kub hnyiab ntawm menthol thaum siv cov koob tshuaj ntau. Tsis tas li ntawd, txij li cov neeg ua haujlwm txias no yuav luag tsis muaj iab thiab mint aroma, lawv tuaj yeem siv rau hauv kev tsim cov khoom noj uas tsis yog mint flavored. Cov tshuaj ua kom txias no kuj muaj cov nyhuv synergistic thaum siv nrog menthol, tsim kom muaj qhov txawv txav.
Cov tawv nqaij txias receptors yog nyob rau hauv lub hauv paus ntawm lub epidermis, {{0}}.1 mus rau 0.2 hli hauv qab ntawm daim tawv nqaij nto, thiab muaj ib txoj kab uas hla ntawm li 1 hli. Thaum qhov kub thiab txias poob mus txog 32 degree, qhov txias receptor pib emit teeb liab. Qhov ntsuas kub qis dua, lub teeb liab muaj zog dua. Thaum kub poob qis dua 13 degree, koj yuav hnov mob, tab sis qhov mob yog hnov los ntawm txawv receptors. Lub qhov ncauj tej zaum yuav rhiab heev rau qhov txias txias dua li cov tawv nqaij sab nrauv vim nws nkag tau yooj yim dua. Qhov kev xav txias ua los ntawm menthol yog xav tias yog los ntawm kev txo qis hauv Ca2+ conductivity.
Cov nyhuv synergistic ntawm ambient kub thiab molecules muaj qhov cuam tshuam loj rau qhov txias txias. Piv txwv li, qhov kub tsis tshua muaj peev xwm txhim kho qhov txias txias ntawm menthol, thaum kub kub tuaj yeem ua qhov txawv. Tsis tas li ntawd, qhov kev xav txias txias kuj muaj feem xyuam rau qhov rhiab heev ntawm tus neeg. Noj menthol ua piv txwv, qhov kev hloov ntawm qhov ncauj qhov ncauj yog 0.02 ~ 10 ug, thiab cov neeg feem coob yog cov pab pawg neeg rhiab heev.
Cov cua txias feem ntau yog soluble hauv cov roj yam tseem ceeb thiab cov hauv paus thiab feem ntau sib xyaw ua ntej siv rau hauv cov khoom kawg. Tus nqi ntawm cov khoom siv txias yog nyob ntawm cov khoom siv thiab feem ntau sib txawv. Ntawm cov khoom noj qab zib, cov pos hniav thiab cov tshuaj txhuam hniav muaj kev siv ntau tshaj plaws, ua raws li cov khoom qab zib thiab caj pas lozenges, thiab lwm yam dej qab zib thiab cov khoom uas muaj cov ntsiab lus dej siab tau qis dua. Tsis tas li ntawd, cov neeg ua haujlwm txias no ua haujlwm zoo tshaj plaws hauv cov tshuab polar, xws li dej haus dua li cov pos hniav. Yog li ntawd, nyob rau hauv tej yam khoom uas daim ntawv thov ntawm cov cua txias yog ib qho nyuaj, cov cua txias yog feem ntau ua rau hauv qab zib coatings kom kov yeej lipophilicity ntawm matrix.
Molecular structural yam ntxwv ntawm cov cua txias
Cov tshuaj ua kom txias molecules feem ntau muaj cov pab pawg uas tuaj yeem tsim cov ntawv cog lus hydrogen, cov pob txha sib txuas ntawm cov pa roj carbon monoxide thiab qhov tsim nyog hydrophilic-lipophilic tshuav nqi. Tus txheeb ze molecular loj feem ntau yog nyob nruab nrab ntawm 150 thiab 350. Cov yam ntxwv ntawm cov tshuaj ua kom txias yog tias lawv tsis zoo li ua kom txias txias. Tsuav lawv nkag mus rau hauv kev sib cuag nrog cov receptors hauv lub qhov ncauj lossis tawv nqaij, lawv yuav ua rau lub siab txias. Rau qee qhov laj thawj, amide cua txias cov neeg ua haujlwm feem ntau tsim kom muaj qhov txias txias sai dua li cov tsis muaj nitrogen, tshwj tsis yog cov menthol.
Kev sib raug zoo ntawm cov qauv molecular thiab kev ua haujlwm ntawm cov neeg ua haujlwm txias tsis tau meej meej txog tam sim no. Raws li tau hais ua ntej, tus neeg ua haujlwm txias molecules feem ntau qhia qee yam khoom. Cov yam ntxwv no tuaj yeem siv los coj tus qauv tsim ntawm tus neeg ua haujlwm txias molecules, tab sis cov khoom no tsis tuaj yeem npog tag nrho cov tebchaw nrog kev ua kom txias. Txij li lipophilicity thiab tsim ntawm hydrogen bonds yog cov ntsiab lus tseem ceeb rau kev ua kom txias txias, feem ntau cov khoom cua txias molecules muaj cov pab pawg ua haujlwm. Cov cua txias tuaj yeem muab faib ua peb pawg raws li lawv cov qauv molecular: menthol thiab nws cov derivatives, amides thiab lwm pawg.
Menthol thiab nws cov derivatives
Rau cov khoom ua kom txias tau ncaj qha los ntawm menthol, qhov kev xav txias ua los ntawm l-menthol derivatives yog qhov muaj zog dua li ntawm d-menthol derivatives. Menthol yog nyob rau hauv EFFA daim ntawv teev cov khoom xyaw uas tso cai nyob rau hauv cov teb chaws Europe, thiab nws FEMA tooj yog 2665. Menthol tshwm sim nyob rau hauv peppermint, thiab steam-distilled Asian peppermint roj feem ntau muaj 75% l-menthol, piv nrog tsuas yog li ntawm 50% nyob rau hauv peppermint li niaj zaus. roj. Neeg Esxias mint yog qhov pheej yig tshaj plaws thiab txhim khu kev qha ntawm ntuj mint (nws tseem tuaj yeem tau txais los ntawm lwm hom mint). Tus nqi ntawm natural menthol feem ntau fluctuates, thaum lub synthetic ib tug kuj ruaj khov, tab sis feem ntau lub ntuj yog pheej yig dua.
Menthol yog cov khoom siv cua txias tshaj plaws. Txij li thaum menthol tuaj yeem tsim qhov txias txias ntawm daim tawv nqaij ntawm qhov ntau npaum li 1%, nws yog tshwj xeeb tshaj yog siv hauv cov tshuaj tsw qab txhua hnub. Cov nyhuv ntawm menthol yog cuam tshuam nrog concentration. Ntawm qhov tsis tshua muaj siab, nws tuaj yeem muab qhov txias txias, thaum nyob rau ntawm qhov siab dua 2% mus rau 5%, nws yuav muaj tshuaj loog hauv zos thiab khaus khaus. Sib txawv ntawm daim ntawv thov ntawm cov khoom noj qab zib, qhov tsis txaus ntawm menthol nyob rau hauv cov nqe lus ntawm tsw thiab saj yog feem ntau tsis yooj yim mus ntes nyob rau hauv txhua hnub flavors. Yog li ntawd, menthol yog ib qho tseem ceeb heev rau kev siv txhua hnub, tab sis menthol yog siv nyob rau hauv siab concentrations. Cov nyhuv irritating, tshwj xeeb tshaj yog rau lub qhov muag, tseem pom tseeb heev.
Qhov cua txias ntawm menthol nyob rau hauv lub qhov ncauj kab noj hniav yog kwv yees li 0.3 ug, thiab cov dej txias ntawm l-menthol yog 45 npaug zog dua li ntawm d-menthol. Vim nws qhov xwm txheej tsis hloov pauv, muaj zog stimulating nyhuv thiab inherent tsw, menthol tau txwv nws daim ntawv thov ua ib tug ua kom txias nyob rau hauv cov zaub mov. Txawm li cas los xij, menthol tseem muaj txiaj ntsig zoo siv rau hauv cov khoom uas mint tsw tau txais, xws li zom cov pos hniav, ua pa fresheners thiab cov khoom siv hauv qhov ncauj. Hauv cov ntawv thov no, menthol feem ntau yog siv nrog lwm yam tsis muaj ntxhiab thiab ua kom txias txias, xws li monomenthol glutarate, uas ua rau lub siab txias dua.
(1) Isomers ntawm menthol thiab cov neeg ua haujlwm txias nrog cov qauv tsim
d-(+)-Neo-menthol yog lub epimer ntawm l-menthol ntawm hydroxyl txoj hauj lwm. Nyob rau hauv EFFA daim ntawv teev cov khoom xyaw flavoring tso cai rau siv nyob rau hauv cov teb chaws Europe, FEMA tus naj npawb yog 2666.
(±) - Menthone, nyob rau hauv EFFA daim ntawv teev cov khoom xyaw flavoring tso cai nyob rau hauv Teb chaws Europe, FEMA tooj yog 2667.
(1)-Isopulegol (Coolant P), in the EFFA list of food flavoring ingredients allowed to be used in Europe, the FEMA number is 2962. Isopulegol usually produces a cooling sensation, has a minty and grassy aroma, and is a little bitter. However, Takasago Company found that high-purity (1)-isopulementol (>99.7%) tsis muaj ntxhiab thiab tuaj yeem siv rau hauv txiv qaub tsw. Muab lub siab tshiab, txias txias. (1)-Isopulegol yog muag raws li lub npe lag luam "Coolant P" los ntawm Takasago Company.
(2) Menthol derivatives
Menthyl acetate yog nyob rau hauv EFFA daim ntawv teev cov khoom xyaw flavoring tso cai nyob rau hauv cov teb chaws Europe, thiab nws cov FEMA tooj yog 2668. Cov compound no yog siv los ua ib tug txias. Kev siv tau tshaj tawm hauv cov ntaub ntawv suav nrog kev siv ua pa tsw qab, tshuaj txhuam hniav, lossis nrog lwm cov tshuaj xws li monomenthyl succinate.
Menthyl lactate(Frescolat ML), nyob rau hauv EFFA daim ntawv teev cov khoom xyaw flavoring tso cai nyob rau hauv Teb chaws Europe, muaj ib tug FEMA tus naj npawb ntawm 3748. Cov compound yog cais raws li ib tug flavorant los ntawm FEMA txawm nws tsis muaj zog minty aroma thiab earthy saj. Nws muab qhov txias txias txias nyob rau hauv lub qhov ncauj thiab muag raws li lub npe lag luam Frescolat ML los ntawm Haarmann & Reimer.
Menthyl glycol carbonate (Frescolat MGC) thiab menthyl propylene glycol carbonate (Frescolat type MPC), ob lub tebchaw yog nyob rau hauv EFFA daim ntawv teev cov khoom noj flavoring tso cai rau siv nyob rau hauv teb chaws Europe, nrog FEMA tooj 3805 thiab 3806 feem. Nyob rau hauv EFFA daim ntawv teev cov khoom xyaw flavoring tso cai rau siv nyob rau hauv cov teb chaws Europe, CAS tus naj npawb ntawm ethylene glycol derivatives yog 156679-39-9, thiab CAS tus naj npawb ntawm qhov tseeb configuration yog l-form yog 156324-78-6. propylene glycol derivative hauv GRAS yog sib xyaw ntawm 1- thiab 2- txoj hauj lwm propylene glycol carbonate. Cov tebchaw no tshwm sim hauv daim ntawv tshaj tawm patent thiab tau hais tias tsim kom muaj qhov txias txias ntawm daim tawv nqaij thiab qhov ncauj mucosa tab sis tsis muaj ntxhiab tsw.
Menthyl 1,2-propanetriol (FrescolatMGA), qhov sib xyaw no yog nyob rau hauv EFFA daim ntawv teev cov khoom noj flavoring uas tau tso cai siv rau hauv Tebchaws Europe, thiab nws cov lej FEMA yog 3807 thiab 3808 raws. Menthone 1,2-glycerol yog muag raws li Frescolat MGA ntawm Haarmann & Reimer (tam sim no Symrise). Ntau cov ntaub ntawv tau tshaj tawm nws daim ntawv thov nyob rau hauv cov khoom noj qab zib formulations, thiab feem ntau nws yog siv nyob rau hauv ua ke nrog rau lwm yam cua txias.
Mono-l-menthol succinate yog nyob rau hauv EFFA daim ntawv teev cov khoom xyaw uas tso cai nyob rau hauv cov teb chaws Europe, thiab nws cov FEMA tooj yog 3810. Txawm hais tias mono-l-menthol succinate tau ib tug paub compound rau ntau tshaj 100 xyoo, nws tseem yog ib tug ntawm cov zoo hluavtaws hluavtaws. Cov neeg ua haujlwm txias tam sim no nyob rau hauv kev ua lag luam. British American Tobacco thawj zaug tshaj tawm nws cov synthesis thiab daim ntawv thov nyob rau hauv luam yeeb nyob rau hauv 1962, thiab nyob rau hauv 1965 qhia nws siv raws li ib tug tsw muaj nyob rau hauv menthol luam yeeb los tso menthol. Lub synthesis ntawm no compound feem ntau kuj yooj yim thiab yuav tau los ntawm reacting menthol nrog succinic anhydride nyob rau hauv ib tug high-pressure los yog alkaline-catalyzed tov. Cov khoom sib xyaw tsis muaj ntxhiab tsw, tuaj yeem tsim qhov txias txias zoo, yog qhov siv tau ntev, thiab pheej yig heev.
Mono-l-(mono)-menthol glutarate (Cooler 2), IFF muag cov tshuaj no (FEMA 4006) raws li ib qho analogue ntawm monomenthol succinate nyob rau hauv lub npe lag luam Cooler 2. Nws cov khoom zoo ib yam li cov succinate. Nyob rau tib qhov concentration (25 mg / L, hauv dej), qhov txias txias yog li 40 vib nas this qeeb, tab sis ntev heev. Tej zaum nws yuav yog tus neeg saib xyuas lub qhov ncauj nrog qhov txias txias tshaj plaws ntawm lub khw. Txawm hais tias qhov sib xyaw no tau paub ntev los lawm, nws tsuas yog nyuam qhuav pib siv rau hauv cov khoom noj qab zib. Ntawm tib hom kev ua kom txias txias molecules, glutarate mono-l-(mono)-menthol ester kuj muaj cov khoom tshwj xeeb, thiab txij li cov khoom sib xyaw yog ib txwm zoo ib yam, nws muaj kev lag luam tseem ceeb hauv kev lag luam nyob sab Europe. Lwm cov khoom ua kom txias sib npaug muaj xws li menthol, menthyl acetate, thiab menthone, tab sis cov khoom ua kom txias no yog luv luv thiab feem ntau muaj qee qhov tsis xav tau. Qhov ntxov tshaj plaws synthesis ntawm no compound yog nyob rau hauv 1928. Nws yog tau los ntawm alcoholysis ntawm dimenthol ester. Zoo ib yam li succinate ester, nws tseem tuaj yeem npaj tau yooj yim los ntawm cov kua qaub anhydride sib xws.
3-(l-menthyl)propyl-1, 2-diol (TK-10, Txias tus neeg sawv cev 10), qhov sib xyaw no yog nyob rau hauv EFFA daim ntawv teev cov khoom xyaw flavoring pub rau siv hauv Tebchaws Europe, FEMA tus lej yog 3784, hauv Takasago Tuam Txhab Cov khoom npe yog TK-10. Ib yam li lwm cov tshuaj menthol-derived cooling agents, l-form menthol-derived 3-(l-menthol)propyl{13}}, 2-diol muaj qhov ua kom txias zoo tshaj plaws. Muaj cov ntawv tshaj tawm patent qhia tias cov khoom siv ntawm 1-acetyl-2- hloov pauv -3-l-menthenylpropane, isomers ntawm l-menthenyl-2S thiab 1-acetyl{22 }} hloov pauv (Hor Ac) derivatives yuav Nws muaj qhov ua kom txias dua, tab sis cov no tseem tsis tau ua lag luam. TK-10 yog tus neeg ua haujlwm txias nrog lub zog txias txias, thiab tus nqi pib hauv lub qhov ncauj yog li 1mg / L. Raws li cov lus ceeb toom, txawm hais tias feem ntau cov neeg xav txog qhov sib xyaw ua kom tsis muaj ntxhiab, qee qhov tseem pom tias nws muaj qee qhov olfactory ntawm menthol, qee qhov khaus thiab iab saj. Ntawm qhov concentration siab dua 50 mg / L, qhov txias txias yog qhov ntev, tab sis qhov saj zoo li menthol tuaj yeem hnov zoo meej. Muaj ntau cov ntaub ntawv qhia txog nws daim ntawv thov hauv cov khoom noj thiab cov khoom noj txhua hnub. Vim tias qhov sib xyaw ua ke no muaj qhov txias txias thiab muaj zog saj, nws tau siv ntau dua hauv cov khoom noj txhua hnub.
3-(l-menthyl)propyl-1, 2-diol muaj ob lub derivatives nrog FEMA tus lej, ib qho yog 3-(l-menthyl)-2-methylpropyl{{ 7}}, 2-diol , FEMA tus lej yog 3849, tab sis kev lag luam me heev; lwm yam yog vanillin 3-(l-menthyl)propyl-1, 2-diol, FEMA tus naj npawb yog 3904, muaj cov ntawv tshaj tawm patent tias nws tuaj yeem siv rau hauv cov khoom noj qab zib formulations nruab nrab.
Amides
Raws li tau hais ua ntej, amide txias cov neeg ua haujlwm tuaj yeem tsim qhov txias txias sai sai, thiab qee qhov ntawm lawv muaj qhov txias txias ntev heev. Cov hauv qab no yog qhov zoo tshaj plaws amide txias tus neeg sawv cev tam sim no ntawm kev ua lag luam. Ntawm cov amide txias cov neeg ua haujlwm, feem ntau ib qho ntawm lub khw yog N-ethyl-p-menthyl-3-amide (WS-3). thiab 2-isopropyl-N,2, 3-trimethylbutanamide (WS-23) (WS-3 thiab WS-23 yog cov cim lag luam ntawm Warner-Lambert Company).
N-ethyl-p-menthyl-3-amide (WS-3), cov tshuaj no yog nyob rau hauv EFFA daim ntawv teev cov khoom noj khoom haus flavoring tso cai rau siv nyob rau hauv teb chaws Europe, thiab nws FEMA tooj yog 3455. WS{{ 6}} tej zaum yuav yog qhov tseem ceeb tshaj plaws ntawm cov khoom ua kom txias, nrog rau qhov cua txias ntawm kwv yees li 0.2 mg/L. Qhov sib xyaw no yog qhov tsis muaj ntxhiab tsw thiab tsuas muaj qhov tsis muaj zog minty aroma. Piv nrog rau menthol, nws tuaj yeem tsim qhov txias txias sai sai thiab rau lub sijhawm ntev. Qhov sib xyaw no yog ib qho ntawm cov neeg ua haujlwm txias tshaj plaws uas tau pom los ntawm Wilkinson Sword hauv nws cov kev tshawb fawb pioneering hauv kev ua haujlwm txias txias. Tom qab ntawd, ntau tus patents tau tshaj tawm nws daim ntawv thov hauv ntau qhov chaw. Lub tuam txhab Warner-Lambert tsis ntev los no tau tshaj tawm nws daim ntawv thov hauv cov khoom noj qab zib formulations.
Givaudan thiab Millennium Chemicals tam sim no muag cov tshuaj no. Txawm hais tias tus qauv peb-seem tsis tau qhia, daim ntawv l-daim ntawv yuav tsum muaj qhov ua kom txias tshaj plaws. Txoj kev synthesis feem ntau yog thawj zaug hloov cov menthol rau hauv menthol chloride, tom qab ntawd npaj cov Grignard reagent sib raug, ua rau cov dej khov qhuav, thiab hloov cov kua qaub rau hauv cov kua qaub chloride, thiab tom qab ntawd mus rau N-ethyl amide.
2-Isopropyl-N,2,3-trimethylbutanamide (Cooler 3, WS-23), cov tshuaj no yog nyob rau hauv EFFA daim ntawv teev cov khoom xyaw flavoring tso cai rau siv nyob rau hauv teb chaws Europe, thiab nws FEMA tus naj npawb yog 3804. 2-Isopropyl Lub npe N,2,3-trimethylbutanamide yog me ntsis ruam; Nws yog lub npe meej dua N-methyl-2-isopropyl-2, 3-dimethylpropionamide. Cov khoom sib xyaw no yog muag raws li lub npe lag luam WS-23 los ntawm qee lub tuam txhab thiab Cooler 3 los ntawm IFF. Zoo li WS-3, qhov sib xyaw no kuj yog ib qho ntawm cov neeg ua haujlwm txias tsim los ntawm Wilkinson Sword. Tam sim no, tus neeg ua haujlwm txias yog siv rau hauv cov khoom noj khoom haus, xws li zom cov pos hniav, tshuaj thiab ua pa fresheners. Cov khoom xyaw ua rau lub siab txias txias tsis muaj iab, hlawv lossis khaus. Tus nqi ntawm tus neeg ua haujlwm txias no tsis ntev los no tau nqis mus txog $ 70 / kg.
Muaj ntau ntau txoj hauv kev los ua ke WS-23, tab sis qhov tseem ceeb nyob hauv kev sib txuas ntawm diisopropylpropylnitrile. Propylonitrile yog thawj zaug alkylated nrog isopropyl bromide kom tau txais diisopropylpropylnitrile, uas yog tom qab ntawd hydrolyzed kom tau carboxylic acid thiab tom qab ntawd hloov mus rau hauv methyl-substituted amide.
2-Pyrrolidone-5-carboxylic acid menthyl ester (Questice), uas yog tus neeg ua haujlwm txias muag nyob rau hauv lub npe lag luam Questice los ntawm Quest International. Derivatives ntawm proline l-form thiab d-daim ntawv tau sau npe, tab sis qhov muag tiag tiag yog sib xyaw ntawm proline l-form thiab d-form, ob qho tib si yog epimeric. lub cev kev sib raug zoo. Txog tam sim no, cov khoom lag luam tau txwv rau kev siv txhua hnub, tab sis txij li cov khoom sib xyaw yog ib qho amide derivative ntawm menthol, daim tawv nqaij thiab qhov ncauj mucosa yog rhiab heev rau nws, thiab nws yog feem ntau siv rau hauv cov khoom noj qab zib.
Lwm cov khoom cua txias
Ntxiv nrog rau cov khoom ua kom txias tau hais los saum toj no, kuj tseem muaj lwm cov khoom ua kom txias.
AG-3-5 (Icilin), ib qho derivative ntawm ectoine-2-ib, tau tshaj tawm los ua kom muaj qhov txias txias. Thaum ntxov li xyoo 1972, nws tau tshaj tawm tias thaum noj tshuaj tsawg (<1mg/kg) was injected into the peritoneum of mammals such as mice, the animals would tremble with cold. When the human body is accidentally exposed to the compound, it produces a cooling sensation that lasts about 15 minutes. After 5 to 10 mg of this compound is dissolved in orange juice and taken, a cooling sensation is produced in the mouth, throat, chest cavity and below. A cooling sensation on the inner surface of the cheeks, arms, and legs has also been reported. The compound has been tested to have very low toxicity, with an LD50 of about 1500 mg/kg, but it is suspected to have mutagenic effects. So far there are no reports on the application of this compound. However, this compound has a strong cooling sensation and has great potential application value.
Methyl-2-(1-pyrrolidinyl)-2-cyclopenten-1-ib (3-MPC), 5-methyl-2-({{7} }}pyrrolidinyl)-2-cyclopentene-1 -ketone (5-MPC) thiab 2,5-dimethyl-4-(1-pyrrolidinyl){{15} }(2H)-furanone (DMPF), peb lub tebchaw no muaj nyob hauv malt thiab yog tsim los ntawm Hofmann thiab cov npoj yaig tau tshaj tawm tias nws tuaj yeem tsim qhov txias txias hauv qhov ncauj thiab tawv nqaij. Cov tebchaw no tau pom thawj zaug hauv Maillard cov tshuaj tiv thaiv ntawm cov piam thaj thiab l-proline. Lawv cov qauv tom qab tau lees paub los ntawm kev sib cais thiab tshuaj lom neeg sib xyaw, thiab lawv tau raug soj ntsuam los ntawm kev ntsuas kev hnov qab los ua kom muaj qhov txias txias.
Cov theem pib ntawm cov tebchaw no yog 5 mus rau 100 npaug siab dua li menthol, tab sis thaum saj 50 npaug siab dua qhov pib, qhov kev xav txias yog instantaneous, muaj zog dua li menthol, thiab kav ntev dua. Txawm hais tias peb lub tebchaw no txhua tus muaj ntxhiab tsw, lawv qhov chaw pib siab dua li menthol, yog li qhov sib piv ntawm qhov ntsuas cua txias / qhov ntsuas kub qis dua. Yog li ntawd, nyob rau hauv cov khoom uas tsis xav tau mint tsw, cov tebchaw no zoo dua li menthol. Kev xaiv tus neeg ua kom txias. Nws tsis paub meej tias cov tebchaw zoo li no tuaj yeem tsim los ntawm kev lag luam, tab sis lawv yuav dhau los ua cov khoom cua txias zoo rau kev lag luam.
4-Methyl-3-(pyrrolidinyl)-2(5H)-furanone (4MPF), kuj muaj nyob rau hauv malt, muaj zog dua thiab tau tshaj tawm tias muaj qhov txias txias hauv qhov ncauj uas yog 35 npaug zog dua menthol. , uas yog hais txog 500 lub sij hawm muaj zog ntawm daim tawv nqaij, thiab qhov kev xav txias yuav kav ntev li ob zaug ntev li menthol.
Mannitol thiab sorbitol, ob lub tebchaw no muaj qhov tshwm sim endothermic hauv qaub ncaug thiab yog li tsim kom muaj cua txias. Raws li cov khoom qab zib uas tsis yog khoom noj khoom haus thiab cov tshuaj tiv thaiv kab mob, lawv tau siv dav hauv cov khoom noj xws li zom cov pos hniav thiab cov pos hniav. .
Methyl salicylate, FEMA tus naj npawb 2745, muaj cov ntxhiab tsw zoo rau lub caij ntuj no thiab tuaj yeem muab lub siab txias txias hauv qee cov khoom noj.
Qhov twg mus yuav tus neeg ua kom txias?
Cua Txias Txias Lwm tus neeg thiab manufacturers-GREEN SPRING®Cov Cuab Yeej Cuab Yeej
Xi'an Green Spring Technology Co., Ltd. Cov khoom siv ua kom txias muaj xws li ws-23, ws-3, ws-5, ws-12, ws-27, mentthyl acetate, menthyl lactate, thiab lwm yam.Peb cov khoom ua raws nrog rau cov qauv kev cai (EC) Tsis muaj 396/2005 thiab Kev Cai Tsis Txaus Siab Tsis Muaj 2023/915, thiab tau lees paub los ntawm BRC, IFS, Halal, Kosher, thiab ISO9001.
GREEN Caij nplooj ntoos hlav®muaj ntau tshaj 23 xyoo ntawm kev sib raug zoo ntawm tus khub, kev txawj ntse hauv kev lag luam, kev tsim kho tshiab thiab kev pabcuam uas txhua tus neeg ntawm GREEN SPRING®coj tuaj rau peb cov neeg siv khoom txhua hnub. Tiv tauj peb rau koj cov kev daws teeb meem nutraceutical thiab kws tshuaj:
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